Fructose (and ofc also HFCS) was recently highlighted for being responsible for gut expansion and engorgement of villi in the intestinal tract.
https://news.weill.cornell.edu/news/2021/08/research-uncovers-how-fructose-in-the-diet-contributes-to-obesity
It has also been linked to reduced dopamine signaling leading to greater ease of metabolic disorders and overeating/food addictions.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5747444/
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