Just because you can’t observe the microscopic event doesn’t mean you can discount the macroscopic effects. When you burn natural gas, water is produced; you don’t need to see the constituent molecules reacting in order to see that water forms and, against all safe lab practice, taste it to confirm its water.
The bonding of water can also be observed in the macro-scale, in the form of snowflakes. Each snowflake has six-sided (or six-fold?) symmetry because of the way that water bonds and freezes.
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