Is grafting residues the same as amino acid sequence engineering

Question

I am looking into consensus tetra-trico-peptide repeat sequences (CTPRs) and these are usually used as protein scaffolds. I just want to confirm that grafting proteins onto the scaffold is not the same as amino acid sequence engineering.

In: Biology

Answer 1

Amino acid sequence engineering, or rather *protein* engineering, is a broad umbrella term. It basically covers anything that involves artificially fusing, cleaving, or otherwise designing and synthetically creating peptides.

So there’s no reason why protein grafts (which are essentially complex fusion proteins) wouldn’t fall under the umbrella of “protein engineering.”