Not trying to be funny, either, but how could an isolated population, of a severely remote/xenophobic island, not just disappear due to the side effects of inbreeding? Do secluded populations eventually become immune to the mutations?
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Ancient populations were also pretty ruthless in exposing children with any sort of defective. The viable ones who could contribute to the group’s welfare might be left alive but not allowed to marry, etc. People are sharp-eyed and would quickly learn the rules about what level of inbreeding was too much. Some of the tribal cultures still have the most elaborate rules about who you can marry.
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