Not trying to be funny, either, but how could an isolated population, of a severely remote/xenophobic island, not just disappear due to the side effects of inbreeding? Do secluded populations eventually become immune to the mutations?
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The side effect of inbreeding is that your child have higher chance of express bad recessive gene. The good thing of inbreeding is that you know who had bad genes and exclude them from the gene pool.
Habsburg is the worse because of how the way their inheritance rule works, they cannot get rid of individual who express bad genes. Unlucky for them, many of those defective member end up on the throne, but many of Habsburg member does not have as much health issue despite equally inbred.
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