Not trying to be funny, either, but how could an isolated population, of a severely remote/xenophobic island, not just disappear due to the side effects of inbreeding? Do secluded populations eventually become immune to the mutations?
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The estimated population of North Sentinal Island is 50-400 people. Depending on how careful they are with genealogy and how okay they are with polygamy, they might be able to avoid inbreeding altogether. Which is good, because inbreeding isn’t something you can become “immune” to.
Inbreeding is bad because over time, small genetic issues compound and become more and more expressed as the gene pool feeds back into itself. It’s possible to implement some kind of eugenics system wherein those with genetic defects aren’t allowed to reproduce, which would reduce the risk of inbreeding. But that’s kind of dystopia nightmare-fuel.
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