Certain tumour cells are more likely to metastasize( move from one organ to another) than others. Some cells(like alveolar cells of lungs) have better chance of surviving in other organs because of their metabolic requirements. Hepatic ( liver) cells have specific conditions required for proliferation while alveolar cells have less specific requirements.
Secondly, if biopsy has been performed, looking at the tumour constituency, it can be determined where it originates from.
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