: If Gut microbioma is massively involved in parkinson, depression etc like science begins to state , why people who underwent months of antibiotics to treat tuberculosis dont develop these illnesses !?
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Because it’s not 100% causative to these diseases. It may be an important factor, but evidently not the *only* one.
The appendix has a big role to play in this, its job is to keep a ‘back-up’ of your good bacteria. So when something comes through and wipes out your gut bacteria, say antibiotics, or food poisoning and many stops to the toilet; it can just pop the right types back in and you’re good to go. It’s by no means a useless organ. One that’s not necessary to survive, but you need it to thrive.
To change the gut bacteria balance long-term, you need a steady diet change. This allows for the bacteria that thrive on the food type you’re eating to wage war on the other types and win the territory battle for your bowels. This is what’s linked to those diseases mentioned, if you eat a high sugar diet, parkinson’s is more likely due to the bacteria high sugar diets cultivate
>If Gut microbioma is massively involved in parkinson, depression etc like science begins to state , why people who underwent months of antibiotics to treat tuberculosis dont develop these illnesses !?
“Massively involved” is not a term likely to show up in a paper’s conclusion. Re-read your source and the exact nature of the connection might answer your question.
There are a few reasons:
Firstly, in your example you speak of months of TB treatment. The TB bacteria is relatively uncommon type of bacteria called Mycobacteria. This is mainly due to a unique type of cell wall. TB antibiotics in general are quite selective in targeting mycobacteria because of this unique cell wall, as the mechanisms often target these unique cell well properties. Thus TB treatment would have a smaller effect on the gut microbiome (GMB) than general broad spectrum antibiotics, as mycobacteria aren’t well represented in the GMB.
Secondly, the role of the GMB is only recently being discovered and described. Changes to the GMB *can be* associated with the onset of psychiatric disorders, but it is rarely if ever the sole cause. IMO, a lot more evidnce is required before a direct 1:1 causal relationship can ever be implied between a “bad” GMB and mental illness.
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