Side to side, nothing at all. You can only be a step or two off center.
Front to back is a different matter. If everyone is at the front or back of the plane, the elevator control is used to raise or lower the nose to keep it level. That’s normally no problem. But there are limits. The center of gravity needs to be within those limits or it is possible for the plane to become uncontrollable when the elevator is no longer enough to keep it level.
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