They are not fried, their numbers decrease just temporarily. SSRI or SNRI (antidepressant or anxiety drugs) users also experience a similar change thanks to receptor down-regulation. If they suddenly stop using their medicine they suffer from some side effects that takes a few weeks before the body turns back to normal but in some cases it takes longer. I don’t know how much it takes with opiods though and there can also be some long-term effects sometimes.
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