If you mean is there a difference between taking 2x as much once a day, versus taking half a dose twice a day, then yes.
Not every medication absorbs or acts as long as others. Your body may also react and metabolize medications at different speeds.
An example. I take an inhaled corticosteroid twice a day (every 12 hours actually). It ensures that my lungs recieved a measured dose at regular intervals and there is always medication working in my system. My medication lasts in the body about 15-16 hours (according to my doctor), so taking 4 inhalations in the morning does not provide for medication for the last 8h or so. I notice if I miss a dose, but taking 3 or 4 inhalations instead of 2, doesn’t help my lungs feel better all day.
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