Sedation and Psychiatric Drugs

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After an awesome on caffeine that explained a lot about adenosine and adenosine receptors, I was wondering: antidepressants largely act on Serotonin, and antipsychotics largely act on Dopamine. Why is it that some of the antidepressants and almost all the antipsychotics are sedating? And why does it seem like sedation/alertness from some SSRI/SNRIs is so different from person to person?

In: Biology