My son had a rare neurotransmitter disease where his body didn’t make seratonin or dopamine. This affected everything from sleep to his moods and more importantly, his ability to walk or talk. He couldn’t even lift his head. Nothing we could give him helped that because there isn’t a drug that has been developed that passes the blood brain barrier. He later got gene therapy surgery that greatly improved his quality of life when he started making dopamine on his own. But the blood brain barrier was the main issue with the drugs currently available
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