won’t it be more efficient if delevered transdermally ? because it will directly get absorbed into blood stream whereas in oral route, it has to go through gastric channel and liver thus decreasing its efficiency.
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The skin is pretty good at keeping things _out_ of the blood stream. That is actually the primary purpose of skin – to keep the outside separate from the insides.
Some stuff can be absorbed through the skin, sure, but not everything can and even the things that can be are often absorbed slower than an injection or a pill.
We use transdermal patches where they make sense, but we can’t use them for everything because the skin is good at its job.
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