won’t it be more efficient if delevered transdermally ? because it will directly get absorbed into blood stream whereas in oral route, it has to go through gastric channel and liver thus decreasing its efficiency.
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Because to be absorbed transdermally, any molecule (drug) needs to be somewhat lipophilic (Lipid or fat ‘loving’) and non-polar. This is to be able to pass through the cell membranes of skin and other tissues which are made of phospholipids which are non-polar (and like dissolves like). Molecules also need to be small enough to enter other paracellular pathways (between cells) for absorption in the case that they cannot pass through biological tissues. This is the short version, there is a lot of nuance to drug absorption, which is why a lot of research is done to formulate products for optimal transdermal absorption. However, the drug in question needs to be an ideal candidate at first, or else no amount of formulation will help.
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