Chemically, they are different substances.
* [Ibuprofen](https://en.wikipedia.org/wiki/Ibuprofen), C13H18O2
* [Acetaminophen, aka Paracetamol](https://en.wikipedia.org/wiki/Paracetamol), C8H9NO2
* [Aspirin, aka acetylsalicylic acid](https://en.wikipedia.org/wiki/Aspirin), C9H8O4
Acetaminophen, aka Paracetamol is a “non-opioid analgesic and antipyretic” that seems to be going out of favour in medical circles as it does little to reduce fever.
Asprin and Ibuprofen are both classed as “nonsteroidal anti-inflammatories” (NSAID). Both can reduce blood clotting and cause bleeding.
They are really very different drugs, and have people and situations where one is recommended over the other.
If you want some “explain it like I have a medical degree” look here
[google scholar search – review ](https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=review+Ibuprofen%2C+Acetaminophen%2C+Aspirin&btnG=)
If you want to know about side effects this is worth reading
[Over the counter overdose – A Review of Ibuprofen, Acetaminophen, and Aspirin Toxicity in Adults](https://journals.lww.com/aenjournal/abstract/2008/10000/over_the_counter_overdoses__a_review_of_ibuprofen,.12.aspx)
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