There isnt really science behind it, and definitly not physics.
at best there is psychology behind it or maybe sociology. basically “harmony” is a made up and cultural thing. what we call harmony was just made up by the ancient greeks. other cultures have their own version of harmony we find discordent (india is a good example).
at some age after hearing your culture’s harmony long enough, your brain just goes “I guess this is what sounds good” https://youtu.be/IMjlZ-0Qm2Q
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