Vitamins are chemical substances just like all other matter. Synthetic vs natural only ever says something about the origin of a substance; for many things, like vitamins, it’s perfectly possible to recreate it in a test tube, so there is no real difference between the synthetic or natural versions. The result can be packaged into a pill, and nuances of bioavailability aside, that vitamin (say, C) will be used by your body no differently than if you’d gotten it from eating a bunch of citrus fruits.
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