Aside from the energy storage issue other people have alluded to, there’s also a mechanical component: when you contract your muscles, they can block your blood flow (for example when clenching your hand into a fist). The same can happen in your arms and legs when doing consistent or repeated contractions (like holding a weight, flexing muscles, etc). Aside from your energy stores running out, the new energy has a much harder time getting to your muscle cells, and the “garbage” coming out of your muscles cells finds it harder to leave.
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