The incidence of those genes in the general population and whether the disease is a recessive or dominant trait. The incidence in the population is obviously determined by just how the genetic disease harms you. If it’s extremely deadly and his at an early age then it’s probably going to be very rare due to natural selection. Conversely if it doesn’t really affect you until old age then there’s a lot less of an evolutionary pressure to eliminate it from the gene pool.
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