What does it mean to have a higher prevalence of IgG4 antibodies?

Question

[https://www.science.org/doi/10.1126/sciimmunol.ade2798](https://www.science.org/doi/10.1126/sciimmunol.ade2798)

The study above does not answer these questions and indeed proposes that further research should consider related questions about the effects of the Sarscov2 vaccine, but I am curious more about IgG4 aside from the above study–is it better to have a higher prevalence of IgG3 and IgG1 for defending against viruses? What would happen if there were a higher prevalence of IgG4 from a theoretical medical perspective? What would the effects on defending against viruses be?

In: 5

Answer 1

This question is better suited for r/askscience, the folks over there are experts on topics like this. I’d try posting this question over there.