What does Poison ivy actually do to you?

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Inspired by the small yet extremely annoying rash on my hand right now. What is actually happening to you when you are infected with poison ivy and why?

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Major Pro Tip – To relieve the insane itch the blisters have for 3-4 hours, run hot water over the blistered area (not boiling). It feels sooo good and biologically it forces the nerve’s transient receptor potential (TRP) channels that control the perception of itch to dump their signaling chemicals all at once.
These same channels found on nerve cells are crucial for sensing temperature and overwhelming them with heat interferes with their ability to transmit the itch a few hours.

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