What exactly happens in the human body during a blood transfusion? How is the extra blood accommodated?
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New blood is inserted into circulation and flows throughout the body just as the old blood does. So long as you’re replacing the amount of blood and blood products that were lost, there is really no need for accommodation. If you’re overdoing it on red blood cells, increased viscosity and clotting can occur. Overdoing it on plasma or saline to a mild extent can be filtered out by the kidneys; but to an excessive extent can cause fluid overload, resulting in backup into the tissues (including the lungs) and strain the heart.
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