Muscles are expensive to maintain, so whenever the body doesn’t have enough food to do so (malnutrition) or it feels the muscles aren’t used and are a waste of ressources (long-term immobilisation), it gets rid of them. There are also other causes of course (for example, when the nerves of a muscle aren’t functional, it’s cut from the brain and stimulation, thus is considered useless and is wasted ; or when an old person falls and can’t get up, hours of muscles being pressured by bones in the same place ends up killing them).
It shows up in blood works while it’s ongoing because the muscle cells release their contents on death, and those can be measured.
As for the muscles coming back, depends on the cause, but usually they can (malnutrition is curable), though it can be hard on vulnerable people already fragilized.
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