It depends. They would want to do almost anything they can to replace them. There are a lot of people who have spent a lot of time to prepare for the show. This is their livelihood. Some theaters have contingency plans for things like this or just an actor getting sick. Actors might have practiced a bit in each others roles and can step in if they have to. Lines might be changed around a bit between actors in some cases. Actors who have played on a previous production of the same play might be asked to join as a replacement. They would do whatever they can to replace the actor.
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