Looked most of the way down and no one mentioned build up of acid in muscles. I’m no expert, but I believe a person with higher endurance can push their muscles harder/longer. Muscles just literally give up at some point. You will not be able to move your leg with enough stength to actually run, then eventually you will not even be able to stand. I believe it’s lactic acid — a quick Bing will certainly tell you more than I can.
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