The most difficult part is sourcing the materials, from the gases/chems used in purification/centrifuge, to the very specific strategic minerals or precision-made tools (like tubings, etc.) needed.
Anti-proliferation laws, especially on “dual use” stuff keeps a lot of stuff out of “bad hands”. It’s laws, not science or technology so much, as that’s all too easy to get, as looking into Dr.Abdul Qadeer Khan will show.
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