The chemical reaction is a nerve reaction, and the not LI5 [wiki page is about TRPV1](https://en.wikipedia.org/wiki/TRPV1). It is a chemical in nerves that is responsible for detecting “Yes, that’s hot” and the way the two chemicals (TRPV1 and capsaicin, the pepper chemical) interact triggers that “Yes, that’s hot” reaction even when it’s not actually high temperatures.
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