Context: I’m trying to understand how someone can have nomal Hb and low ferritin
In: 3
Anemia is a deficiency in hemoglobin (Hb) or hematocrit (Hct). It is a specific lab value definition, not diagnosed just based on symptoms. It leads to decreased oxygen carrying capacity and therefore fatigue. There are many, many causes of anemia that fall into two categories: excessive destruction of old RBCs or insufficient production of new RBCs.
Iron deficiency is a one cause of anemia that leads to insufficient production of RBCs. Iron is a critical component of Hb so without it, the bone marrow factory can’t keep up with the demand. Folate deficiency or a set of diseases called thalassemias also can cause a production-deficient anemia. In the case of low ferritin and normal Hb, that probably means the patient is simply running out of iron stores and is likely about to develop an iron deficiency anemia.
Again, there are many other causes. For example, sickle cell disease/trait leads to RBCs getting deformed and then destroyed earlier than the normal ~120 day life span. This sometimes occurs in episodes and often requires a blood transfusion if severe enough.
Latest Answers