Not what causes it, but why they have the illness.
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I research this. It’s not certain why some people are more prone than others. Much of it centers around how many new experiences the immune system had early in life.
Here’s an analogy. It’s very much like developing a phobia. First contact usually involves a perfect storm of unpleasant factors that leads you to associate a normal stimulus as unusually terrible. Then when you see it again, your body overreacts which itself is even more stressful on the body, which makes it think the harmless thing is even worse than originally expected. Anaphylaxis is basically an immune panic attack when the immune system begins to trigger itself, which causes a larger reaction, which causes more immune activation, etc until it becomes an emergency
Part of building immune tolerance requires kids to be exposed to things early, when the immune system is less “fearful” or reactive, so it remembers later in life that just because something’s unusual don’t make it scary. You can desensitize people later on in life but it’s harder
Anything that encourages that feedback loop, whether it’s an abundance of histamine cells, a co infection, or lack of antiinflammatory cells, can all make initial contact go bad or spin things out of control later. Could be genes, could be the gut, could be bad luck
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