Needle size and sharpness. Some fluids need a larger needle to pas through, and some needles aren’t perfect out of the package. Also, experience of the needle-pusher comes into play (the needle needs to go straight in, straight out, and a perfect depth).
Also, the fluid itself is pushing outward from the injection site into nerve endings, which adds at least a small amount of discomfort to the mix.
This isn;’t even mentioning the miraiad of physiological and immunosuppressive reactions your body ignites at the site, as well, and the body can react quite differently each time.
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