What specifically is the cause of the “empty/hollow” feeling many depressed people talk about having in their chest?

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What specifically is the cause of the “empty/hollow” feeling many depressed people talk about having in their chest?

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We don’t really know. Intense emotional stress will weaken your immune system. This can actually cause you to have low levels of inflammation all over your body whin in turn can cause all sorts of pains and heart irregularities. If you ever experienced intense grief you know a “broken heart” isn’t just a metaphor and the pain is quite really. Depression is similar to that effect while it also affects the area in your brain responsible for pain wich might be related.

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