The honest answer is we don’t know.
There’s a good reason for this. We can analyze urine and even blood but what we need to be able to do is monitor neurotransmitters in real time. The problem with this is it’s dangerous. Normally folks can volunteer for dangerous procedures but anyone volunteering to put probes in their brain might not understand the risk enough to consent.
So until we can do that, most of these drugs are pure guesswork. The clinical trials reveal as much – sometimes they’re more effective than placebo, sometimes not. The only common link for effective medication studied appears to be adjuvant therapy, leading many to believe the therapy is actually doing the heavy lifting.
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