Macronutrients (protein/carb/fat) are extracted from natural food sources. Though i dont see any reason we cant artificially synthesize them, it would be more costly/tedious than extraction due to their relative complexity. Vitamins and minerals are (as a general rule; some vitamins are p big) simpler/smaller molecules so some are naturally sourced and some are artificial depending on feasibility, cost. Btw, important to note that on a molecular level, natural vs artificial are literally the same thing.
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