Alloy steel and titanium are non-toxic (many metals are) and when bone encounters titanium it reacts similarly to a bone graft, which is to say it continues to grow properly. Bone would react differently to copper, copper can rupture cell membranes in bacteria! It isn’t about the immune system; this is like getting shot vs getting sick. Your body can’t function if something is inside of it tearing it apart like a molecular weed wacker. Your immune system can fight sick, it can’t and doesn’t fight heavy metal poisoning. In general, it is hard to get a heavy metal poisoning from titanium, it isn’t impossible, but it doesn’t happen from having a surgical implant.
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