This is not really a ELI5 topic. This sorta thing is a doctorate study. But to if you want understand pain and pain receptors at a very rudimentary form imagine it like you are on you bicycle and witnessing a fight and a kid getting knocked out.
You want to ride home on your bicycle and tell your mom what happened.
Only on your ride home, you notice the street you’re riding on has construction signs and a buncha back goes and you can’t ride through (narcotics, mu receptors).
So you decide your going to ride around all that on your way home on the sidewalk but it is also barricaded off and it abruptly ends ending up in a grass patch (NSAIDs/Acetaminophen)
So you say “fuck it” and ditch your bike where it stands and your going to run across the grass to your house to go tell mom what happens, only to find there’s some stupid big ass fence in the way (etc. Pathways, alpha 2 blockers, misc pain pathways ) and you can’t actually get home so you just stand there and yell from where you’re at and your mom can’t really figure out wtf is going on.
Yeah. It’s kinda like that. Mom is the brain which interprets and reacts to all the information. The incident/fight is the painful incident and the messenger, little kid on the bike, is the communicator.
If the communicator can’t relay the message of pain the brain can’t process what to make of it or how to respond to the incident so nothing happens.
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