Imagine you’re playing with your friends and accidentally scrape your knee. Ouch! That hurts, right? So, there’s this thing in our body called “Substance P” that acts like a messenger. When you get hurt, it tells your brain, “Hey, something’s not right here. You need to feel pain so you know something’s wrong.”
Now, about pain killers. When you take a pain killer, it intersperses with Substance P from telling your brain about the pain. That’s how you start to feel better after taking a pain killer.
Imagine you’re playing with your friends and accidentally scrape your knee. Ouch! That hurts, right? So, there’s this thing in our body called “Substance P” that acts like a messenger. When you get hurt, it tells your brain, “Hey, something’s not right here. You need to feel pain so you know something’s wrong.”
Now, about pain killers. When you take a pain killer, it intersperses with Substance P from telling your brain about the pain. That’s how you start to feel better after taking a pain killer.
Imagine you’re playing with your friends and accidentally scrape your knee. Ouch! That hurts, right? So, there’s this thing in our body called “Substance P” that acts like a messenger. When you get hurt, it tells your brain, “Hey, something’s not right here. You need to feel pain so you know something’s wrong.”
Now, about pain killers. When you take a pain killer, it intersperses with Substance P from telling your brain about the pain. That’s how you start to feel better after taking a pain killer.
‘Gate Theory’ of opiates suggests- rather than receptors opiates bind to in the brain- that similar receptors in the spinal cord are occupied by the opiate molecules. This theory posits that (yet undiscovered) ‘Substance-P’ is prevented from delivering the pain signal to be transferred up to the brain, where we would begin to feel it.
My own experience, using prescription opiates to treat a broken foot bone: I was mystified, as all pain had gone away. I poked the injury. Nothing. I poked harder. Nothing. Doped up, I gave it a good squeeze…. ouch! Pain will break through, if overcomes the inhibitory effects of opiates.
Tolerance builds up to opiates, sadly, so chronic injury with unchanged opiate doses will eventually be the new baseline for pain.
‘Gate Theory’ of opiates suggests- rather than receptors opiates bind to in the brain- that similar receptors in the spinal cord are occupied by the opiate molecules. This theory posits that (yet undiscovered) ‘Substance-P’ is prevented from delivering the pain signal to be transferred up to the brain, where we would begin to feel it.
My own experience, using prescription opiates to treat a broken foot bone: I was mystified, as all pain had gone away. I poked the injury. Nothing. I poked harder. Nothing. Doped up, I gave it a good squeeze…. ouch! Pain will break through, if overcomes the inhibitory effects of opiates.
Tolerance builds up to opiates, sadly, so chronic injury with unchanged opiate doses will eventually be the new baseline for pain.
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