Asking this as I have a horrible throat infection making it incredibly painful to swallow, and therefore difficult to eat and drink. I have to stay on top of my painkillers every four hours or the pain starts to come back, I’d just love to know how this actually works.
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‘Gate Theory’ of opiates suggests- rather than receptors opiates bind to in the brain- that similar receptors in the spinal cord are occupied by the opiate molecules. This theory posits that (yet undiscovered) ‘Substance-P’ is prevented from delivering the pain signal to be transferred up to the brain, where we would begin to feel it.
My own experience, using prescription opiates to treat a broken foot bone: I was mystified, as all pain had gone away. I poked the injury. Nothing. I poked harder. Nothing. Doped up, I gave it a good squeeze…. ouch! Pain will break through, if overcomes the inhibitory effects of opiates.
Tolerance builds up to opiates, sadly, so chronic injury with unchanged opiate doses will eventually be the new baseline for pain.
I was in excruciating pain due to a herniated discs.
They tried OxyContin and Percocet…. no effect.
They finally started giving my Dilaudid injections ….. the pain was still there, but it was duller and “far away”.
The Dilaudid at least allowed me to rest a little until I could get surgery done.
I loathe recreational opiate users, their choice to abuse opioids for strictly recreational use are making it hard for people with actual medical needs to access effective medicines.
Here’s a quick 10 second explanation from Dr. Noc. [how ibuprofen know where pain](https://www.tiktok.com/t/ZTR3FY9A7/)
Here’s a quick 10 second explanation from Dr. Noc. [how ibuprofen know where pain](https://www.tiktok.com/t/ZTR3FY9A7/)
I was in excruciating pain due to a herniated discs.
They tried OxyContin and Percocet…. no effect.
They finally started giving my Dilaudid injections ….. the pain was still there, but it was duller and “far away”.
The Dilaudid at least allowed me to rest a little until I could get surgery done.
I loathe recreational opiate users, their choice to abuse opioids for strictly recreational use are making it hard for people with actual medical needs to access effective medicines.
can someone maybe explain the difference between ibuprofen and diclofenac? i believe second reliefs my muscle and joint pain better than ibu.
Here’s a quick 10 second explanation from Dr. Noc. [how ibuprofen know where pain](https://www.tiktok.com/t/ZTR3FY9A7/)
can someone maybe explain the difference between ibuprofen and diclofenac? i believe second reliefs my muscle and joint pain better than ibu.
I was in excruciating pain due to a herniated discs.
They tried OxyContin and Percocet…. no effect.
They finally started giving my Dilaudid injections ….. the pain was still there, but it was duller and “far away”.
The Dilaudid at least allowed me to rest a little until I could get surgery done.
I loathe recreational opiate users, their choice to abuse opioids for strictly recreational use are making it hard for people with actual medical needs to access effective medicines.
can someone maybe explain the difference between ibuprofen and diclofenac? i believe second reliefs my muscle and joint pain better than ibu.
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