You kind of have it the other way around. The reason why we no longer have so many of those ancient large animals is because they were big walking piles of meat, and humans were very good at hunting them.
The timeline of extinction for most megafauna tends to correlate pretty strongly with the spread of homo sapiens. The survival strategy of “become too big for predators to bother with” worked fairly well until humans came around with spears and coordinated teamwork which made it much harder to survive with just sheer size alone.
There are other reasons too, like the changing climate, but my understanding is that human hunting is thought to be the primary cause.
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