Horses, in general, are not capable of running for hours on end. Yes, they are fast, but they run in short bursts, just like any other ungulate out there.
It’s why humans succeeded so fantastically as persistence hunters: while we cannot run very fast, we _can_ run for much longer than horses or deer, allowing us to “run them down” into exhaustion.
Even during the Pony Express, said riders switched horses every 10-15 miles. The horses weren’t generally able to go further at full tilt without needing dramatically longer recovery periods. Meanwhile humans can go 50-100km without stopping, and some ultramarathoners have been able to go up to 560km in 80 hours without needing to rest or sleep.
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