why are serotonin–norepinephrine reuptake inhibitors used for anxiety when norepinephrine causes anxiety?
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Like almost anything in the body: too much of a thing can be a problem just as too little of that same thing is also a problem. Also, when it comes to hormones and neurotransmitters, they often do more than one thing in the body and can either cause something or it’s opposite to occur. Norepinephrine is a stress modulator, among other things. Too much of it can cause feelings of anxiety in response to stress, but too little of it can cause lethargy, attention disorders, and anxiety as well. It also has an effect on emotions. SNRIs work by blocking the re-uptake of Serotonin and Norepinephrine. Re-uptake is absorption. Blocking re-uptake (absorption) leads to higher levels available for use by the body. The science behind SNRIs show that increasing levels of serotonin and norepinephrine can help alleviate symptoms of depression and anxiety.
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