Smallpox for example and Polio (almost)
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the a effort it took to do thatot small pox and polio took several decades and several billions of dollars and it was primarly accomplished by ensuring the general population is immunized.
as it turns out if a disease no longer has a viable vector to transmit or manifest symptoms it stops being able to spread efficiencty and “stalls out”, Extend this effort for a couple of decades and all current strains die out.
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