What is it that’s different about different people that means caffeine (or maybe all drugs that alter mental states?) can affect different people in different ways.
For me coffee has no noticeable affect on my energy at all seems to actually work quite well as a warm drink before sleeping. But for others it can give them more energy or even make them anxious?
In: 3
The effect of most drugs may vary with the dosage. As the human body tries to get rid of xenobiotics (substances that are not Food per se), it changes the chemical properties of the substances to accelerate excretion (e.g. increase water solubility). This is mostly done with specific liver enzymes, that can be expressed differently throughout a population, which means some have more (fast metabolizer) and some have less (slow metabolizer). The faster you metabolize and excrete a substance, the lower is your blood concentration.
Of course, the stimulant effect of caffeine can be antagonized by other substances, as well as underlying conditions, that alter Neurotransmitter concentrations, such as ADHD.
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