im no expert but i know that its easy to think that our cells seem so incredible that they must be perfect. the mechanisms work most of the time but they ocassionally make mistakes. when dna gets replicated i believe mistakes are made every 10,000 base pairs on average. there are proteins that correct those but even they can be wrong
i think a good analogy to cells would be a factory. factories are efficient because they have many distincts parts that are designed to only do a single task. they call this an assembly line. it works well and mistakes are rare but they still happen. these mistakes are best thought of as random with the cause generally being unimportant. although, if you get a surge in mistakes then that would require further investigation
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