Why can humans build up a tolerance to some medications but not others?

Question

Edit: Thank you very much for the gold! I hope the comments made to this post were as helpful to others as they were to me.

In: Biology

Answer 1

To add on to what others have said, [this study](https://www.sciencedaily.com/releases/2019/06/190613143629.htm#:~:text=According%20to%20Maini%20Rekdal%2C%20gut,helpful%2C%22%20Maini%20Rekdal%20said.) shows that some drug tolerance could be caused by gut microbes. If you’re taking a prescription every day and a certain microbe in your gut can eat it that microbe will increase in numbers over time, and as it increases it will consume more of your medication.