Edit: Thank you very much for the gold! I hope the comments made to this post were as helpful to others as they were to me.
In: Biology
Drugs that act as agonists lead to tolerance. The relevant receptor is stimulated eventually causing the nervous system to reduce the number/frequency of receptors in response. This allows you to build tolerance. Some drugs don’t have this effect and can be the opposite (antagonists). The more you use an agonist drug the more tolerant you will become as the number of receptors you have for it decreases. So you may be more tolerant than another person due to this. Opposite happens when using an antagonist drug, that causes addiction. That’s my simplified version that I can remember from university!
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