Edit: Thank you very much for the gold! I hope the comments made to this post were as helpful to others as they were to me.
In: Biology
Depends if the body has a system which is able to measure the influence of the medication and also counter balance the effect. This is called homeostasis and is mostly a problem for long time steady dose medications or drugs ie. coffein that you throw in every three hours is easier to get a tolerance than ibuprofen that you take every two weeks.
Some drugs target system that are just not balanced in the body, insulin would be an example as far as i know. The amount of insulin is control by bloodsugar and as insulin effects bloodsugar it is its own regulator making an additional feedback loop unnecessary. But take that with a grain of salt i could imagine such a loop exists and i just dont know about it.
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