Edit: Thank you very much for the gold! I hope the comments made to this post were as helpful to others as they were to me.
In: Biology
Vast topic- here is a quick attempt-
1- receptors get used to drug. Take some pain medicine- body makes more receptors for that medicine- now you need more pain medicine to fill up those receptors. Feed your puppy- he grows bigger- now you need to feed it more
2- liver- some medication rev up /down the system. Produce or reduce the amount of enzyme. Alcohol is good examples… 1 beer after a long time is a good buzz.. drink it everyday- you don’t event feel it.
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