I think it just depends on if the cell has a counteracting/balancing mechanism or not.
Generally, signaling molecules like hormones or neurotransmitters have what’s called a negative feedback loop. If the amount is too high, certain mechanisms work on reducing it and vise versa.
So external influencers might force the cell to change some of its structure (e.g reducing the amount of receptors), to accommodate the new change.
Of course the change might be on certain levels that don’t change the outcome, for example anabolic steroids are taken to increase testosterone to levels higher than 10 folds and yet, muscles still respond to that change with no counteraction, while the testes would shrink in an attempt to reduce the high level of testosterone.
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