why does one strand have to lag? doesn’t DNA polymerase III bind to 3′ OH ends of RNA primers and then synthesize in a 5′ to 3′ direction? don’t all the RNA primers have a 3′ end for the polymerase to bind to? so why is one strand able to synthesize continuously while the other does it bit by bit?
please help ya girl broke down while studying in Starbucks because she couldn’t understand even after way too long
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Remember, DNA has an *anti*-parallel structure. The 5′ end of one strand matches with the 3′ end of the opposite strand. In the replication bubble there are two replication forks.
DNA extends 5′ to 3′ only. You can’t write upstream of the primer, basically.
Are you essentially asking why Okazaki fragments are needed?
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